The plague of 1348 is most significant because

cassius, casca, and their allies plant false documents to manipulate brutus to join their cause to remove caesar. after doing so, they visit brutus at night in his home to persuade him of their views. there they plan caesar's death. brutus is troubled but refuses to confide in his devoted wife, portia. on 15 march, caesar's wife, calpurnia, urges him not to go to the senate. she has had visionary dreams and fears the portents of the overnight storms.

c hydrophobia is the answer