1 Give the mechanism for the synthesis of tyrbostin from benzaldehyde. Show how
the carbanion is generated from malononitrile (NCCH2CN) and stabilised (5 marks).
Show the reaction of the carbanion with the benzaldehyde (5 marks). Show how the
resulting alkoxide (O-) is protonated (5 marks). Show how the alkene bond is formed
(5 marks)
CN
ON
&
NCCH2CN
Piperidine
Aldehyde
Tyrphostin
ted Kingdom)
Focus
Answers: 1
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1 Give the mechanism for the synthesis of tyrbostin from benzaldehyde. Show how
the carbanion is ge...
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