Fill in the blank. At pH 6.0 the N-terminus of His-His-His-His would have a Entry field with correct answer positive charge. The C-terminus would have a Entry field with correct answer negative charge. Since the pKa for His is 6.0, essentially half of the residues would carry a Entry field with correct answer positive charge on their side chains, so that the charge per residue could be considered to be Entry field with incorrect answer 2.0 . The result would be a net charge on the tetrapeptide of Entry field with incorrect answer 1.0 . Partially correct answer. Your answer is partially correct. Try again. The tetrapeptide would be Entry field with correct answer less soluble in water than Histidine itself. When the carbon bonds are formed between the carboxylate and amino groups to form the tetrapeptide, the groups that would interact with water are lost.