The most reactive metal groups on the periodic table are... Groups I & II
Groups II & III
Groups VI & VIII
Group VII & VIII

Groups I & II

Explanation:

The most reactive metal groups on the periodic table are metals of group 1 and II.

Group I elements are the alkali metals

Group II elements are the alkali earth metals

Therefore, elements in groups I and II are the most reactive metallic groups.

Group I elements prefers to lose one electron to attain an octet configuration.

Group II elements prefers to lose two electrons.

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the old alchemists made significant contributions to science even though there starting premises were off a bit. their conclusions after failure would steer them into better directions for investigation. science is no more than close observation and the initial mistakes result in rethinking and retrying experiments.