Inosine monophosphate is a branch point for the synthesis of a variety of purine nucleotides. Match the appropriate reaction for the synthesis of either AMP or GMP: 1) AMP A) condensation with Asp 2) GMP B) oxidative hydration C) transamination with Gln D) release of fumarate

The generation of AMP takes place by the reaction involving condensation with Asp and the reaction in which fumarate is release. On the other hand, the generation of GMP takes place at the time of oxidative hydration and during transamination with glutamine. Hence, for AMP option A and D is correct, and for GMP option B and C is correct.

Explanation:

A) The production of arginosuccinate and AMP takes place when condensation of citrulline takes place with aspartic acid. It is an energy-dependent reaction, which results in the hydrolysis of ATP to AMP.  

B) The liberation of GMP takes place during the oxidation of amino acids.  

C) The production of glutamate and aspartate takes place respectively during the transfer of amino group from glutamine to oxaloacetate, in the process hydrolyzation of GTP takes place to GMP.  

D) The formation of arginine and fumarate takes place during the conversion of arginosuccinate, in the process ATP is hydrolyzed and the generation of AMP takes place.  

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