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Chemistry, 24.06.2020 01:01 arrissa1234hinkle
Phosphofructokinase is a four‑subunit protein with four active sites. Phosphofructokinase catalyzes step 3 of glycolysis, converting fructose‑6‑phosphate to fructose‑1,6‑bisphosphate. Phosphoenolpyruvate (PEP) is the product of step 9 of glycolysis. The PEP concentration in the cell affects phosphofructokinase activity. Select the true statements about PEP regulation of phosphofructokinase.
1. PEP is a feedback inhibitor of phosphofructokinase.
2. The apparent affinity of phosphofructokinase for its substrate increases when PEP binds.
3. PEP is a positive effector of phosphofructokinase.
4. PEP inhibition of phosphofructokinase yields a sigmoidal velocity versus substrate curve.
5. PEP competes with fructose-6-phosphate for the active site of phosphofructokinase.
6. The binding of PEP to one phosphofructokinase subunit causes a conformation change that affects the ability of the substrate to bind to the other subunits.
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Phosphofructokinase is a four‑subunit protein with four active sites. Phosphofructokinase catalyzes...
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