1. Similarities between alchemy and chemistry include
A. a desire to change base metals such as lead into gold.
B. use of experimentation and reason.
C. a desire to understand and manipulate matter.
D. the foundation on supernatural beliefs.

I think its B

B or C

Explanation:

Alchemy rely a lot on the spiritual connections to the four elements and they are fire, water, earth and air while chemistry is a lot more logical, factual and scientific based. Also, chemistry is considered as science, while alchemy is not.  

Alchemy was based more on experimentation and had little basis in science. Chemistry utilizes both experimentation and scientific practices. Modern chemistry basically relies on scientific theories and experimental results, but the alchemy was a blend of myths, religion, magic, astrology, philosophy, and spirituality.

the answer is definitely c.