Asp-Ser-Arg-Leu-Ser-Lys-Thr-Met-Tyr -Ser-Ile-Glu-Ala-Pro-Ala-Lys-Leu-As p-Trp-Glu-Gln-Asn-Met-Ala-Leu Asp-Ser-Arg-Leu-Ser-Lys-Thr-Met-Tyr -Ser-Ile-Glu-Ala-Pro-Ala-Lys-Leu-As p-Trp-Glu-Gln-Asn-Met-Ala-Leu How many peptide fragments would result from cleaving the sequence with each of the given reagents?

Four fragments with Ala-Leu as residues

Explanation:

A protein is a word that describes any of numerous large, complex naturally-produced molecules composed of one or more long chains of amino acids (also called Polypeptide) in which the amino acid groups are held together by peptide bonds.

Long peptides making up a can be cut into smaller fragments by using certain chemical reagents or enzymes that cuts it at specific sites leaving amino acid residues. Proteolytic enzyme too can be used to cleave peptides in a process called proteolysis. Example of such enzyme is Trypsin and it makes cut at the carboxyl group of arginine and lysine unless its followed by proline.

One of such chemical reagent as mentioned above include the Cyanogen Bromide written as CNBr that cleaves proteins after methionine (Met) side chains.

This chemical usually cleave the amino acid methionine at the carboxyl terminal.

From the above protein sequence using CNBr the number of peptide fragments formed after cleaving with cyanogen bromide is 4.

Asp-Ser-Arg-Leu-Ser-Lys-Thr-Met;

Tyr-Ser-Ile-Glu-Ala-Pro-Ala-Lys-Leu-Asp-Trp-Glu-Gln-Asn-Met ;

Ala-Leu Asp-Ser-Arg-Leu-Ser-Lys-Thr-Met;

Tyr-Ser-Ile-Glu-Ala-Pro-Ala-Lys-Leu-Asp-Trp-Glu-Gln-Asn-Met;

With Ala-Leu as residues.

Proteolysis simply involve the hydrolysis of proteins into peptides and amino acids; in this context but especially as part of the digestion of food.

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