Ionization State of Histidine Each ionizable group of an amino acid can exist in one of two states, charged or neutral. The electric charge on the functional group is determined by the relationship between its pKa and the pH of the solution. This relationship is described by the Henderson-Hasselbalch equation.

(a) Histidine has three ionizable functional groups. Write the equilibrium equations for its three ionizations and assign the proper pKa for each ionization. Draw the structure of histi- dine in each ionization state. What is the net charge on the his- tidine molecule in each ionization state?

(b) Draw the structures of the predominant ionization state of histidine at pH 1, 4, 8, and 12. Note that the ionization state can be approximated by treating each ionizable group independently.

mechanics (greek   is that area of science concerned with the behaviour of physical bodies when subjected to forces or displacements, and the subsequent effects of the bodies on their environment. the scientific discipline has its origins in ancient greece with the writings of aristotle and archimedes[1][2][3] (see history of classical mechanics and timeline of classical mechanics). during the early modern period, scientists such as galileo, kepler, and newton laid the foundation for what is now known as classical mechanics. it is a branch of classical physics that deals with particles that are either at rest or are moving with velocities significantly less than the speed of light. it can also be defined as a branch of science which deals with the motion of and forces on objects. the field is yet less widely understood in terms of quantum theory.

explanation:

qualitative observation deals with data that can be observed with our senses: sight, smell, touch, taste, and hearing. they do not involve measurements or numbers. for instance, colors, shapes, and textures of objects are all qualitative observations.