What is a significant advantage to the cell in having pyruvate dehydrogenase consist of a large

  Pyruvate dehydrogenase consists of three enzymes: -Pyruvate dehydrogenase, Dihydrolipoyl transacetylase, and Dihydrolipoyl dehydrogenase. The short distance between these enzymes allows channeling of substrates which minimizes the side reactions.

Glycolysis or glycolysis (from glycos, sugar, lysis, breakdown) is the metabolic pathway responsible for oxidizing glucose to obtain energy for the cell. It consists of 10 consecutive enzymatic reactions that convert glucose into two molecules of pyruvate, which is able to follow other metabolic pathways and thus continue to deliver energy to the body