Which kind of metabolic poison would most directly interfere with glycolysis?

An agent that closely mimics the structure of glucose but isn't metabolized.

Explanation:

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Glycolysis is carried out when glucose is turned into piruvate via metabolism, nonetheless, when an agent that closely mimics the structure of glucose, for instance its isomers, but isn't metabolized. Since it is not recognized by the involved enzymes and the process can't be carried out properly because no piruvate and energy are produced.

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3 hours because it is a decent distance.