In a particular enzyme, an alanine residue is located in a cleft where the substrate binds. a mutation that changes this residue to a glycine has no effect on activity; however, another mutation, which changes the alanine to a glutamate residue, leads to a complete loss of activity. provide a brief explanation for these observations.
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In a particular enzyme, an alanine residue is located in a cleft where the substrate binds. a mutati...
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