Which three statements accurately describe the blood buffering system in humans? the blood buffering system depends on the ionization of h2po–4 . the blood buffering system is facilitated by the enzyme carbonic anhydrase, which interconverts carbon dioxide and water to carbonic acid, ionizing into bicarbonate and h+ . the blood buffering system utilizes the h2co3 / hco–3 conjugate acid/base pair. the blood buffering system utilizes the acetic acid/acetate conjugate acid/base pair. the blood buffering system maintains the ph of blood near 7.4.