what method should you use to separate this sample of mixture?

a mixture of two components with very different boiling points.

a. fractional distillation
b. fractional crystallization
c. column chromatography
d. paper chromatography
e. simple distillation

The answer to your question is: E. Simple distillation

Explanation:

A. Fractional distillation    This method is used to separate mixtures that have close boiling points.

B. Fractional crystallization  This method is used to separate mixtures with different solubilities.

C. Column chromatography  This method is used to separate mixtures based in their absorption.

D. Paper chromatography  This method is used to separate mixtures based in their capacity to displace on a paper.

E. Simple distillation This method is used to separate mixtures that have with very different boiling points.