In principle, at least one way to increase the concentration of g6p is to drive the equilibrium to the right by increasing the intracellular concentrations of pi and/or glucose. assuming a fixed concentration of pi at 5.0 mm, how high would be the intracellular concentration of glucose have to be to give an equilibrium concentration of glucose−6−phosphate of 0.25 mm (the normal physiological concentration)? would this route be reasonable, given the maximum solubility of glucose is less than 1 m?