Which type of macromolecules are not soluble in water?

Definition:  

A macromolecule is a very large molecule, such as protein, commonly created by the polymerization of smaller subunits (monomers). They are typically composed of thousands of atoms or more.

Explanation:

The polar covalently bonded water molecules act to exclude non-polar molecules that  lack polar covalent bonds and vice versa.

Conclusion:

The macromolecule which are polar covalently bondeed are soluble in water while the non-polar covalently bonded macromolecules are not soluble like lipid.

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