Mutation of which of the following would result in the least disruption during development of a frog embryo?
a. ribosomal protein gene
b. rna polymerase gene
c. homeotic gene
d. melanin gene

The correct answer is option D- Melanin gene.

All the other options such as ribosomal protein gene, RNA polymerase gene and homeotic gene plays a role in the development of frog embryo, on the contrary melanin gene does not.

Melanin gene activates cells called melanocyets which control the complexion of a skin in organisms. There are multiple colors of skin depending upon the activity of melanin gene present in the body.