In the first step of glycolysis, glucose can be phosphorylated to glucose-6-phosphate, because in the first step of glycolysis, glucose can be phosphorylated to glucose-6-phosphate, because a phosphoanhydride bond has higher energy of hydrolysis than is required for formation of a phosphoester bond. the reaction does not require an enzyme. the reaction is highly reversible. transfer of a phosphate from atp to glucose is endergonic. all of the above are correct.