Why can a cell not survive under conditions of unlimited growth?

Cell depend on dependent upon exogenous signals for survival, growth, and proliferation. The growth factor influencing cell growth can be examined using a signal molecule called interleukin-3(IL-3).

The cells having dose of interleukin-3 below threshold undergo apoptosis or natural death, otherwise unlimited growth can cause cancer.

As per the study, high rate of growth factor results in shortening of G1 phase of the cell cycle and leads to more rapid proliferative expansion. the cells which grows under high concentrations of growth factor are more susceptible  to cell death during growth factor withdrawal.

Hence, cell are not able to survive under conditions of unlimited growth.

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