Bile salts bind at their hydrophobic regions to large fat globules within the chyme that enters the duodenum. bile salts break up the fat globule into smaller fat droplets. this role of bile salts is best described as bile salts bind at their hydrophobic regions to large fat globules within the chyme that enters the duodenum. bile salts break up the fat globule into smaller fat droplets. this role of bile salts is best described as lipid emulsification lipid digestion lipid ingestion lipid absorption