Long-term use of can lead to permanent hearing loss, limb spasms, nervous system and brain damage, bone marrow damage, and death. a. heroin b. dextromethorphan c. inhalants d. cocaine

The correct answer is option c, that is, inhalants.

Explanation:

Inhalants refer to the chemicals, which are generally found in household items, the sale of which is generally not monitored. These chemical discharge toxic vapors, which impart effects mostly like depressants. The short term use of inhalants can possibly lead to loss of sensation, hallucination, and unconsciousness.  

However, the long-term effect of inhalants can result in limb spasms, permanent hearing loss, brain and nervous system damage, and destruction of bone marrow. Even there is a probability of death due to the suffocation of heart failure when someone takes overdose of inhalants.