What happens on a molecular level when you make slime?

The glue has long flexible molecules in it called polymers. These polymer molecules slide past each other as a liquid.

Borax in water forms an ion called the borate ion. When the borax solution is added to the glue solution, the borate ions help link the long polymer molecules to each other so they cannot move and flow as easily.

When enough polymer molecules get hooked together in the right way, the glue solution changes from being very liquidy to a rubbery kind of stuff that we call slime!