In normal skeletal muscle tissue, binding of acetylcholine to its receptors at the neuromuscular junction results in:

Opening of Na+ and K+ Explanation: Acetycholine binding opens Na+ and K+ ion channels in the receptors that allow simultaneous passage of Naâş into the muscle fiber and Kâş out of the muscle fiber. More Naâş ions enter than Kâş ions exit, which produces a local change in the membrane potential called the end plate potential. Binding of acetycholine to receptor proteins opens Na+ and K+ channels resulting in jump in resting membrane potential(RMP) from -90mV to +75mV forming an end-plate potential (EPP).

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