which small-scale mutation would be most likely to have a catastrophic effect on the functioning of a protein?

i think its the first one

this is a good question! i'll do some research and come back when i have the answer!

helicase, i think thats it

in 1859, charles darwin set out his theory of evolution by natural selection as an explanation for adaptation and speciation. he defined natural selection as the "principle by which each slight variation [of a trait], if useful, is preserved".