Which of the following can be cofactors?

Cofactors can either be ions, such as zinc and iron ions, or organic molecules, such as vitamins or vitamin-derived molecules. Many of these cofactors will attach near the substrate binding site to facilitate the binding of the substrate to the enzyme.

kamsahamnida have a great day

explanation:

the fossil record extends back to a dog-like ancestor some 55 million years ago, which gave rise to the first horse-like species 55 to 42 million years ago in the genus eohippus.