what types of effect(s) (none, harmful, or beneficial) are base substitution mutations likely to have?

answer >   yes we do, women; have three holes, urethral opening(pee hole, vagina, and the women pee/girls pee out of the urethra like the men do; only they have a single opening to pee/ejaculate.   (sorry if i'm too forward with this, but this is for a biology class, isn't it? )

hope that !         : )