The worst kind of sadness is not being able to explain why.

basically thats pain.Because when u cant explain, U will probably feel shame.Second, u wont feel like other people who could explain especially with good grammar words based on my experience.Just talk to ur self in the mirror and practice :).I have been through this types of situtions... If the that didnt help take a very deep breath and look at people around u but remember there is no difference between u and them u make mistakes they make mistakes too no one is perfectly perfect. they are humans u are human too also dont mind some dirty eye contact from themtry ur best and neglect them as much as possible

the binding of the substrate is dictated by the shape of each molecule. side chains on the enzyme interact with the substrate in a specific way, resulting in the making and breaking of bonds.