1. Compare and contrast how the normal and mutated proteins adhered to the cell membrane? How did the mutation impact the function of the CFTR proteina
2. What happened to the green active site of the protein in the mutated CFTR proteina
Why is this a problema
3. Hypothesize what might happen if the deletion mutation was at the end of the gene
rather than towards the beginning.
4. Explain how the CFTR gene leads to the creation of the CFTR protein
5. Approximate how many minutes it took to complete this
activity (a close estimate is
fine). The complete CFTR gene is actually 230,000 base pairs long. In this activity,
you transcribed and translated a section that was 96 base pairs long. Use a ratio to
determine how long it would take you to transcribe and translate the entire CFTR
protein,
6. There are actually many different types of mutations that can occur in the CFTR
gene, any of which can cause cystic fibrosis. More than 70% of cystic fibrosis cases
are caused by a 3-nucleotide deletion that results in the loss of phenylalanine at the
508th amino acid. Research and determine the second and third most common
types of mutations that cause cystic fibrosis. Cite your source(s).
7. Construct an explanation based on evidence for how the structure of DNA
determines the structure of proteins, which carry out essential functions of life through
systems of specialized cells. Research and cite at least one source for your
explanation