The final progression from adenoma to carcinoma can be caused by loss of TP53, a tumor suppressor gene. In order for this progression to occur, allele(s) must be lost, in contrast with mutation of the gene earlier in the process. (Assume haploinsufficiency does not affect any of the genes in this process.)

weathering - colorado river carves land in arizona to form the grand canyon. cracks form in a sandstone wall surrounding a house. a marble statue near the science museum is changing color due to rainfall

erosion - after a rainstorm, soil and rock piees litter the roadways. the sand dunes in the sahara desert are changing shape.

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air enters through the nose, moves through the nasal cavity, the pharynx, the larynx, enters the trachea, moves through the bronchi andbronchioles till the alveoli.