g in sickle cell anemia, there is a mutation in the beta subunit of hemoglobin where a glutamic acid is replaced with valine. How would that change affect the molecule

Answer and explanation:

Sickle cell anemia is a type of anemia that occurs because of a mutation in the HBB gene, which codifies for the beta subunit of hemoglobin, producing an abnormal beta-globin called Hemoglobin S o HbS. This anomalous beta subunit is a product of the replacement of the amino acid glutamic acid by the amino acid valine at position 6, resulting in a beta-globin that forms a long and rigid molecule turning red blood cells shape into a sickle one, condemning erythrocytes to a premature death (which will cause the anemia). Another complication patients with sickle cell anemia can have is the blocking of blood vessels because of the abnormal and rigid shape of their red blood cells.

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