Gonorrhea is a sexually transmitted infection (STI) caused by the diplococcus Neisseria gonorrhoeae, commonly called gonococcus (GC). This organism developed resistance to penicillin and tetracycline in the 1980s, after which fluoroquinolones were the recommended drugs for treating GC. Subsequent resistance to the fluoroquinolones has led to the current recommended treatment of injected ceftriaxone in combination with oral azithromycin. Although this approach continues to be effective, recent data from the CDC indicates that resistance to azithromycin is emerging. Initially, GC was treated with penicillin, which targets , and tetracycline which targets .