Inflammation can be local or systemic. what are the most prominent systemic manifestations of inflammation? mark all that apply.

The most prominent systemic manifestations of inflammation include the following:

- The acute-phase reaction, modifications in WBC count and fever.

- The liver rises the synthesis of acute-phase proteins such as Fibrinogen, C-reactive protein (CRP) and serum amyloid A protein (SAA) that all serve unalike defense functions. 

- Increase in WBC count. Normal is 4-10. 

- Sepsis can take place.