The three-dimensional structure of a functional protein is altered by intense heat or nonphysiological ph even though peptide bonds may not break. such inactivation is called denaturation, and denatured enzymes are nonfunctional. explain why.

In biochemistry, enzymes are protein catalysts of the body that speeds up certain specific metabolic reactions in the body. They word in the concept of lock-and-key theory or induced fitting. These two theories are all based on the shape and size of the enzyme's active site that could accommodate the substrate. So, the main function of the enzyme is dependent on its shape. Therefore, when an enzyme undergoes denaturation, its orientation and shape changes. For example, a beta pleated sheet may change to an alpha helix orientation. As a consequence, the number and capacity of active sites changes. Hence, the enzyme becomes nonfunctional.

Schools are being forced to embrace computers. unlike their "digital immigrant" teachers, these students are "digital natives", born into a world where technology is an integral part of everyday life. almost every student has access to a multitude of computers, laptops and tablet devices. it would be crazy to assume an assignment would  notbe written on computer in this day and age.many schools now have a 1-to-1 computer policy, and many districts and states in the united states have mandated computers or ipads across the state for every student,  including los angeles, the second largest school district in the country.but the thing is, when they tried it in la, it wasn't the success they hoped for. that's because the tablets weren't used as much as they expected. rather, it appeared there was a gap between the digital native's love of technology and their use of it in the classroom.this conflicted relationship with computers is also underscored by much of the literature on education. it is also highlighted in professional development and conferences such as  edutech.