Explain why the patient with the lowest levels of the tpmt enzyme has the greatest number of side effects when exposed to a drug containing a thiopurine.

TPMT enzyme stands for Thiopurine methyltransferase or thiopurine S-methyltransferase. It is an enzyme that metabolizes thiopurine drugs. 

Patients with the lowest level of the tpmt enzyme has the greatest number of side effects when exposed to a drug containing a thiopurine because it can't totally metabolize the thiopurine drug and there are more excess thiopurine in the body than normal. 

In some developing nations the percentage of the animal protein from fish in the diet can be as high as 25 percent.  about 85% of fish caught is used for human consumption.  the remainder is converted into fishmeal and fish oil.