Explain how Cystic fibrosis individuals have protection against typhoid.

Cystic fibros will be protected from infections. Even though two of it can kill it still will have protection against typhoid.

typhi are free to attack the underlying tissue, which lacks this defense mechanism." Since abnormal CFTR binds poorly to S. typhi, cystic fibrosis gene carriers would be protected from this infectious process and thus spared the high mortality associated with typhoid fever.

The gene mutation that causes cystic fibrosis also appears to protect against infection with typhoid fever bacteria, a study supported by the National Institute of Allergy and Infectious Diseases (NIAID) has found. The finding could explain why an estimated 12 million people in the United States carry the gene for such a highly fatal childhood disease. Researchers led by Gerald Pier, Ph.D., of Brigham and Women's Hospital and Harvard Medical School in Boston, report the finding in the May 7, 1998, issue of the journal Nature

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