Cellular differentiation progressively restricts cell fate because the unexpressed genes in the cell:Select all that apply become more densely packed with nucleosomes accumulate both point mutations and deletions accumulate point mutations undergo irreversible repression accumulate deletions.

undergo irreversible repression

Explanation:

Cellular differentiation refers to the process by which one cell and/or cell population divides and differentiates into more specialized cells. During cell fate differentiation, epigenetic marks modify chromatin structure in order to hamper the accessibility of the transcriptional machinery and transcriptional factors to different genes, which are irreversibly repressed. These epigenetic marks include DNA methylation and histone modifications (e.g., histone acetylation, histone methylation, etc). For example, it has been shown that DNA methylation and histone H3 lysine 27 tri‐methylation (H3K27me3) are epigenetic repressive marks on genomic regions that play a major role in gene expression programs during cell fate differentiation.

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