The mitochondria of eukaryotic cells contain two forms of the EF G protein. EF G1mt acts an elongation factor as expected, but EF G2mt acts as a ribosome recycling factor. Individuals with certain single nucleotide polymorphisms (SNPs) in the EF G2mt gene are known to have an increased number of side effects associated with taking statin drugs that treat high cholesterol. The most common side effect is muscle weakness, but they can be as severe as muscle breakdown and liver failure. Propose a mechanism by which SNPs in the EF G2mt gene may lead to these side effects.

The correct answer is - polymorphism mechanism.

Explanation:

Polymorphism mechanism in mitochondrial elongation factor gene EFG2: It involves escalates the atorvastatin toxicity and affects the cell respiratory function. Polymorphisms within the EFG2 factor gene lead to the implication in disease. This gene factor may result in adverse drug reactions such as STATIN, that can leads to side effect to the condition that can affect skeletal muscle severely.

EFG2 plays an essential role which is specific in mitochondrial ribosome recycling. EFG2mt gene is required for cell growth on galactose medium using small interfering RNA splicing of expression in human cell lines.

Such mutation exhibits an atorvastatin-sensitive phenotype and shows less respiratory capacity. this concludes that the first phenotype associated with SNPs in the EFG2mt gene and implicates the human EFG2mt gene as a pharmacogenetic gene for stain toxicity in humans.

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