How are single-gene disease different from other types of disease?​

Explanation:

Single gene disorders are among the most well-understood genetic disorders given their straightforward inheritance patterns (recessive or dominant) and relatively simple genetic etiology. Although the majority of these diseases are rare, in total, they affect millions of Americans. Some of the more common single-gene disorders include cystic fibrosis, hemochromatosis, Tay-Sachs, and sickle cell anemia.

substitution is the answer in this case