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In the ovary, oocytes are held at metaphase II of meiosis until fertilization. How is this
block released?
O Progesterone activates C-Mos, which phosphorylates maturation promotion factor
(MPF).
O A Ca2+ influx induces the activity of calmodulin, which induces Camodulin
dependent kinase (CAM PKII) and calpain and they degrade cystostatic factor (CSF).
o Calmodulin dependent kinase II (CamkII) and calpain are activated by progesterone
and they degrade maturation promotion factor (MPF).
o Progesterone activates c-Mos, which phosphorylates cytostatic factor (CSF)
releasing the block.
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In the ovary, oocytes are held at metaphase II of meiosis until fertilization. How is this
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