ASAP PLZ What type of structure is most like to fail due to the material that it was built from having small cracks or weaknesses

Could someone me with number one you

Scenario #2 in 2001, a population of 2,500 poison dart frogs lived in the amazon rain forest. due to increased deforestation, the population dwindled to 25 frogs in 2019. new government regulations were enacted in 2022, successfully putting an end to the deforestation of the amazon rain forest. once deforestation was stopped, the poison dart frog population was able to recover. by 2050, the population reached 8,000 frogs, of that population, 20 are homozygous recessive for being spotted (ss genotype). q2- ? q- p- p2- 2pq-

What does the positioning of transcription factors determine?