One difference between gene mutation and chromosomal mutation that

c. A chromosomal mutation can change the total number of chromosomes in the cell.

Explanation:

A gene mutation affects a single gene, and replication error is the main cause of gene mutation. A chromosomal mutation affects one part of chromosome or full chromosome. error in meiosis is the main cause of chromosomal mutation. Both mutations are responsible for a change in DNA. A chromosomal mutation leads to the change in total number of chromosomes in the cell.

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