When would a mutation in a DNA sequence most likely occur

Acquired (or somatic) mutations occur at some time during a person's life and are present only in certain cells, not in every cell in the body. These changes can be caused by environmental factors such as ultraviolet radiation from the sun, or can occur if an error is made as DNA copies itself during cell division.

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as in mitosis, dna replication occurs during interphase.   in meiosis, it occurs specifically in s phase of interphase 1.

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