K. N. is a 24 y. o. woman who presents to the clinic complaining of sudden urgency to urinate, frequent urination, and pain with urination. Symptoms began approximately 48 hours ago. She awoke from sleep with urgency and suprapubic discomfort two nights ago. Her urine now has a strong odor and a cloudy appearance. She has no fever. History:

UTI at 30,14, and 8 months ago
Iron deficiency anemia
Gonorrhea and chlamydia 2 years ago
Denies tobacco use
Social alcohol and marijuana use
Sexually active with multiple partners
On Phenazopyridine, Ortho-Novum, and Ferrous sulfate
Allergy â to Trimethoprim-Sulfamethoxazole combination â hives with pruritus
Clinical Manifestations
BP 100/60 Pulse 74 Resp. Rate 15 Temperature 98.2
WBC 6,400 Urinalysis â SP 1.035 pH 5.5 Positive for Leukoesterase, Nitrites, and E. coli, trace blood
Diagnosis?
Treatment
-Use of Fluroquinolones and nitrofurantoin

What is the relationship between Nitrites and E. coli?