Since transport of materials in and out of the cell can only happen at the cell's surface, what happens as cells get larger? How does this impose a limit on cell size?

The surface area/volume ratio will decrease

Explanation:

How does this impose a limit on cell size?

Because the ability of a cell to exchange substances with its environment is proportional to its surface area.

Hence, if surface area/volume decrease and get too small, surface area is not sufficient to take up substances needed to support metabolism or get rid of wastes.

a scenario where a cell may be needed to perform a form of endocytosis is when transporting large molecules. a scenario where a cell may be needed to perform a form of exocytosis is when releasing the large molecule from the cell.

a chain link fence because there so tiny even my albino donkey can't get out