Histones are small proteins with a strong positive charge at physiological pH. They are found in the nuclei of eukaryotic cells and package DNA into nucleosomes, the fundamental structural units of chromatin. Based only on this description, what two forms of chromatography could you use, one after the other, to separate histones from other cellular proteins? Explain your reasoning.

Two modes of chromatography that could be used over and over, based on characteristics of histones throughout the issue, are:

Explanation:

A stationary step, consisting of such a polymeric material with numerous pores of various sizes. The larger proteins would travel further as the solvent system comprising the analytes flows through the paper chromatography and therefore will be separated first. That was because their greater size does not in itself allow the pores found in the polymer to get trapped. Tiny proteins such as histones, and on the other hand, can pass slowly across the process to have been eluted later.

As even the histone properties at biological pH are strongly positively charged, through the use of highly reactive particles as when the stationary step will allow histones to connect to themselves and now all the proteins, as well as favorable proteins that are poorly absorbed, would be eluted. Many positively charged molecules, that aren't as highly charged at around the same pH as histones, will stay throughout the stationary step, however, based on whose net charge, should flow independently of histones.

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an organism's phenotype is the  form of a trait  that it  displays. for  flowercolor, a pea  plant  can  display  a phenotype of purple or white flowers. an organism's  genotype  is the alleles of a gene it contains. based on his data, mendel concluded that a phenotype can be  determined  by more than one  genotype.