Explain the contribution of antigenic determinant in false negative and false positive tests

Explanation:

Much attention has been paid to the specificity and sensitivity of this assay since regular ELISA screening of blood donors for anti-HIV antibodies was implemented. It was found that inadequate coating of the microtitre plates with HIV-antigen could lead to false negative results. It is important that the ELISA test kit manufacturers use control systems that guarantee adequate antigen coating.

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