Identify events that contribute to the termination of a response in the GPCR, or 7TM receptor, pathway. Select all that apply.

Multiple choices:

1. G? dissociates from the G?? subunits.

2. The ligand dissociates from the receptor, which resumes its inactive conformation.

3. The receptor is inactivated by phosphorylation of Ser or other residues on its intracellular domain.

4. G? releases GDP and binds GTP.

5. G? hydrolyzes GTP to GDP and Pi.

Answers

The ligand dissociates from the receptor, which resumes its inactive conformation

The receptor is inactivated by phosphorylation of Ser or other residues on its intracellular domain

G? hydrolyzes GTP to GDP and Pi

Explanation:

The GPCRs known in full as G protein-coupled receptors are viewed by many as the largest group of membrane proteins that are found in human genome. They share a common architecture. The seven-transmembrane (7TM) receptors are mostly used interchangeably with the GPCRs even though there are known receptors that have seven membrane domains and do not just signal through the G proteins.