What factors challenge the stability of an organism?i

Abiotic factors.

Explanation:

Abiotic factors such as temperature and humidity etc challenge the stability of an organism by providing the harsh environment. This harsh environment disturbs the stability of the organism. Increase in temperature and very less or high humidity imbalance the enzyme activity which disturbs the whole functioning of the body of organism. So for chemical processes in the body, suitable temperature is required.

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genetic variation can be caused by mutation (which can create entirely new alleles in a population), random mating, random fertilization, and recombination between homologous chromosomes during meiosis (which reshuffles alleles within an organism's offspring).