You are a virologist interested in studying the evolution of viral genomes. You are studying two newly isolated viral strains and have sequenced their genomes. You find that the genome of strain 1 contains 25% A, 55% G, 20% C, and 10% T. You report that you have isolated a virus with a single-stranded DNA genome. Based on what evidence can you make this conclusion

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Explanation:

In double-stranded DNA, the ratio of purine bases (Adenine and Guanine) and that of pyrimidine bases (Thymine and Cytosine) is 1:1 according to Chargaff's rule. This means that the percentage of Adenine must be equal to that of Guanine while that of Thymine must also be equal to Cytosine.

However, in the case of the newly isolated viral strain, the amount of Adenine (25%) and Guanine (55%) vary while that of Thymine (10%) and Cytosine (20%) also vary. This is in contrast to Chargaff's rule. Hence, the isolated virus is a single-stranded DNA virus instead of a double-stranded.

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