Gonorrhea is a sexually transmitted infection (STI) caused by the diplococcus Neisseria gonorrhoeae, commonly called gonococcus (GC). This organism developed resistance to penicillin and tetracycline in the 1980s, after which fluoroquinolones were the recommended drugs for treating GC. Subsequent resistance to the fluoroquinolones has led to the current recommended treatment of injected ceftriaxone in combination with oral azithromycin. Although this approach continues to be effective, recent data from the CDC indicates that resistance to azithromycin is emerging. Fluoroquinolones act by inhibiting DNA gyrase, an enzyme involved in DNA replication. Resistance to this antibiotic is most commonly by a. due to a mutation in the gene that encodes RNA polymerase, an example of adaptive resistance. b. a change in the DNA gyrase target, an example of acquired resistance increased efflux of the drug from the target cell, an example of innate resistance. c. a change in the DNA gyrase target, an example of innate resistance. d. enzymatic modification of the ribosomal target, an example of innate resistance.